Causal Relationship Between Average Alcohol Consumption and Risk of Atrial Fibrillation: A Mendelian Randomization Study

HomeCirculation: Genomic and Precision MedicineVol. 16, No. 4Causal Relationship Between Average Alcohol Consumption and Risk of Atrial Fibrillation: A Mendelian Randomization Study No AccessResearch ArticleRequest AccessFull TextAboutView Full TextView PDFView EPUBSections ToolsAdd to favoritesDownload citationsTrack citationsPermissions ShareShare onFacebookTwitterLinked InMendeleyReddit Jump toNo AccessResearch ArticleRequest AccessFull TextCausal Relationship Between Average Alcohol Consumption and Risk of Atrial Fibrillation: A Mendelian Randomization Study Andrea Georgiou, Georgios Georgiopoulos, Dimitrios Delialis, Eleni Maneta, Pier Giorgio Masci, Onisiphoros Neophytou, Dimitrios Tsiachris and Evangelos Evangelou Andrea GeorgiouAndrea Georgiou https://orcid.org/0000-0003-4214-3678 Department of Hygiene and Epidemiology, University of Ioannina Medical School (A.G., E.E.). *A. Georgiou and G. Georgiopoulos contributed equally. Search for more papers by this author , Georgios GeorgiopoulosGeorgios Georgiopoulos https://orcid.org/0000-0001-7661-5253 Clinical Therapeutics, National & Kapodistrian University of Athens School of Medicine, Athens, Greece (G.G., D.D., E.M., O.N.). School of Biomedical Engineering and Imaging Sciences, Kings College London, United Kingdom (G.G., P.G.M.). *A. Georgiou and G. Georgiopoulos contributed equally. Search for more papers by this author , Dimitrios DelialisDimitrios Delialis https://orcid.org/0000-0002-7609-0087 Clinical Therapeutics, National & Kapodistrian University of Athens School of Medicine, Athens, Greece (G.G., D.D., E.M., O.N.). Search for more papers by this author , Eleni ManetaEleni Maneta https://orcid.org/0000-0001-5011-3036 Clinical Therapeutics, National & Kapodistrian University of Athens School of Medicine, Athens, Greece (G.G., D.D., E.M., O.N.). Search for more papers by this author , Pier Giorgio MasciPier Giorgio Masci https://orcid.org/0000-0001-5196-9530 School of Biomedical Engineering and Imaging Sciences, Kings College London, United Kingdom (G.G., P.G.M.). Search for more papers by this author , Onisiphoros NeophytouOnisiphoros Neophytou Clinical Therapeutics, National & Kapodistrian University of Athens School of Medicine, Athens, Greece (G.G., D.D., E.M., O.N.). Search for more papers by this author , Dimitrios TsiachrisDimitrios Tsiachris Athens Medical Center, Greece (D.T.). Search for more papers by this author and Evangelos EvangelouEvangelos Evangelou Correspondence: Evangelos Evangelou, PhD, Associate Professor of Clinical and Molecular Epidemiology, Department of Hygiene and Epidemiology, University of Ioannina Medical School, University Campus, 45110, Ioannina, Greece. Email E-mail Address: [email protected] https://orcid.org/0000-0002-5488-2999 Department of Hygiene and Epidemiology, University of Ioannina Medical School (A.G., E.E.). Department of Epidemiology & Biostatistics, School of Public Health, Imperial College London, United Kingdom (E.E.). Search for more papers by this author Originally published16 May 2023https://doi.org/10.1161/CIRCGEN.122.003766Circulation: Genomic and Precision Medicine. 2023;16:406–408FootnotesFor Sources of Funding and Disclosures, see page 406.*A. Georgiou and G. Georgiopoulos contributed equally.Correspondence: Evangelos Evangelou, PhD, Associate Professor of Clinical and Molecular Epidemiology, Department of Hygiene and Epidemiology, University of Ioannina Medical School, University Campus, 45110, Ioannina, Greece. Email vangelis@uoi.grREFERENCES1. Csengeri D, Sprünker NA, Di Castelnuovo A, Niiranen T, Vishram-Nielsen JK, Costanzo S, Söderberg S, Jensen SM, Vartiainen E, Donati MB, et al. Alcohol consumption, cardiac biomarkers, and risk of atrial fibrillation and adverse outcomes.Eur Heart J. 2021; 42:1170–1177. doi: 10.1093/eurheartj/ehaa953CrossrefMedlineGoogle Scholar2. Lu Y, Guo Y, Lin H, Wang Z, Zheng L. Genetically determined tobacco and alcohol use and risk of atrial fibrillation.BMC Med Genomics. 2021; 14:73. doi: 10.1186/s12920-021-00915-0CrossrefMedlineGoogle Scholar3. Larsson SC, Drca N, Wolk A. Alcohol consumption and risk of atrial fibrillation: a prospective study and dose-response meta-analysis.J Am Coll Cardiol. 2014; 64:281–289. doi: 10.1016/j.jacc.2014.03.048CrossrefMedlineGoogle Scholar4. Evangelou E, Gao H, Chu C, Ntritsos G, Blakeley P, Butts AR, Pazoki R, Suzuki H, Koskeridis F, Yiorkas AM, et al. New alcohol-related genes suggest shared genetic mechanisms with neuropsychiatric disorders.Nat Hum Behav. 2019; 3:950–961. doi: 10.1038/s41562-019-0653-zCrossrefMedlineGoogle Scholar5. Larsson SC, Burgess S, Mason AM, Michaëlsson K. Alcohol consumption and cardiovascular disease.Circ Genom Precis Med. 2020; 13:e002814. doi: 10.1161/CIRCGEN.119.002814LinkGoogle Scholar eLetters(0)eLetters should relate to an article recently published in the journal and are not a forum for providing unpublished data. Comments are reviewed for appropriate use of tone and language. Comments are not peer-reviewed. Acceptable comments are posted to the journal website only. Comments are not published in an issue and are not indexed in PubMed. Comments should be no longer than 500 words and will only be posted online. References are limited to 10. Authors of the article cited in the comment will be invited to reply, as appropriate.Comments and feedback on AHA/ASA Scientific Statements and Guidelines should be directed to the AHA/ASA Manuscript Oversight Committee via its Correspondence page.Sign In to Submit a Response to This Article Previous Back to top Next FiguresReferencesRelatedDetails August 2023Vol 16, Issue 4 Advertisement Article InformationMetrics © 2023 American Heart Association, Inc.https://doi.org/10.1161/CIRCGEN.122.003766PMID: 37191011 Originally publishedMay 16, 2023 KeywordsriskMendelian randomization analysisheart failureatrial fibrillationalcohol-induced disordersPDF download Advertisement SubjectsAgingAtrial FibrillationGeneticsRisk Factors