Recent trends on electrochemical determination of antibiotic Ciprofloxacin in biological fluids, pharmaceutical formulations, environmental resources and foodstuffs: Direct and indirect approaches

In the last few decades, pharmaceuticals, credited with saving millions of lives, have emerged as a new class of environmental contaminants. These compounds can have both chronic and acute harmful effects on aquatic ecosystems and consequently on human health. Therefore, there is an urgent need for the development of extremely sensitive, portable, and low-cost devices to perform analysis. In the present review article, recent reports on the application of various voltammetric and photo-electrochemical techniques using different electrode materials for the determination of antibiotic Ciprofloxacin (CIPRO) are reported. This review provides an insight into direct and indirect electrochemical approaches as well as the photoelectrochemical methods used for the determination of CIPRO. Emphasis is put on the applications of unmodified and modified carbon-based electrodes considering the modifier, supporting electrolytes, analytical method, concentration range, limit of detection, and real matrices. Carbon-based electrodes are the most used materials attributed to their commercial availability, reduced cost, high chemical stability, and non-toxicity.