Trial of Solanezumab in Preclinical Alzheimer’s Disease
医学
肿瘤科
作者
Reisa A. Sperling,Michael Donohue,Rema Raman,Michael S. Rafii,Keith Johnson,Colin L. Masters,Christopher H. van Dyck,Takeshi Iwatsubo,Gad A. Marshall,R. Yaari,Michele Mancini,Karen C. Holdridge,Michael Case,John R. Sims,Paul Aisen
Solanezumab, which targets monomeric amyloid in persons with elevated brain amyloid levels, did not slow cognitive decline as compared with placebo over a period of 240 weeks in persons with preclinical Alzheimer's disease. (Funded by the National Institute on Aging and others; A4 ClinicalTrials.gov number, NCT02008357.).