汉坦病毒
病毒学
生物
体内
体外
凝集素
微生物学
病毒
汉坦病毒
免疫学
生物化学
生物技术
作者
Yajing Zhao,Ningbo Zhao,Yong Cai,Hui Zhang,Jia Li,Jiaqi Liu,Chuantao Ye,Yuan Wang,Yamei Dang,Wanying Li,He Li,Lianqing Zhang,Yuexiang Li,Liang Zhang,Long Cheng,Yangchao Dong,Xu Zhang,Yingfeng Lei,Lu Lu,Yingjuan Wang,Wei Ye,Fanglin Zhang
标识
DOI:10.3389/fcimb.2022.881083
摘要
Hantaan virus (HTNV) is the etiological pathogen of hemorrhagic fever with renal syndrome in East Asia. There are currently no effective therapeutics approved for HTNV and other hantavirus infections. We found that griffithsin (GRFT), an algae-derived lectin with broad-spectrum antiviral activity against various enveloped viruses, can inhibit the growth and spread of HTNV. In vitro experiments using recombinant vesicular stomatitis virus (rVSV) with HTNV glycoproteins as a model revealed that the GRFT inhibited the entry of rVSV-HTNV-G into host cells. In addition, we demonstrated that GRFT prevented authentic HTNV infection in vitro by binding to the viral N -glycans. In vivo experiments showed that GRFT partially protected the suckling mice from death induced by intracranial exposure to HTNV. These results demonstrated that GRFT can be a promising agent for inhibiting HTNV infection.
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