微生物群
生物
利基
生态位
进化生物学
进化动力学
生态学
民族
背景(考古学)
人体微生物群
中性分子进化理论
遗传学
基因
人口
人口学
古生物学
社会学
栖息地
人类学
作者
Xin Wei,Ming-Shian Tsai,Liang Liang,Liuyiqi Jiang,Chia-Jui Hung,Laura L. Jelliffe‐Pawlowski,Larry Rand,M Snyder,Chao Jiang
出处
期刊:Cell Reports
[Elsevier]
日期:2024-04-01
卷期号:43 (4): 114078-114078
标识
DOI:10.1016/j.celrep.2024.114078
摘要
The vaginal microbiome's composition varies among ethnicities. However, the evolutionary landscape of the vaginal microbiome in the multi-ethnic context remains understudied. We perform a systematic evolutionary analysis of 351 vaginal microbiome samples from 35 multi-ethnic pregnant women, in addition to two validation cohorts, totaling 462 samples from 90 women. Microbiome alpha diversity and community state dynamics show strong ethnic signatures. Lactobacillaceae have a higher ratio of non-synonymous to synonymous polymorphism and lower nucleotide diversity than non-Lactobacillaceae in all ethnicities, with a large repertoire of positively selected genes, including the mucin-binding and cell wall anchor genes. These evolutionary dynamics are driven by the long-term evolutionary process unique to the human vaginal niche. Finally, we propose an evolutionary model reflecting the environmental niches of microbes. Our study reveals the extensive ethnic signatures in vaginal microbial ecology and evolution, highlighting the importance of studying the host-microbiome ecosystem from an evolutionary perspective.
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