1083P The analysis molecular characteristics, PD-L1, TMB and MSI in Chinese NF1-mutated NSCLC

The tumor suppressor gene neurofibromin 1 (NF1) is a major regulator of the RAS-MAPK pathway and NF1 mutations have been reported in various cancers including non–small-cell lung cancer (NSCLC). NF1 mutations define a unique population of NSCLC. But best treatment patterns in the NF1 mutation group is unclear. Herein, we assessed the molecular characteristics, tumor mutational burden (TMB), microsatellite instability (MSI) and PD-L1 expression in Chinese NF1-mutated NSCLC to explore the possibility of Immunotherapy.