益生菌
安慰剂
银屑病
医学
随机对照试验
银屑病面积及严重程度指数
临床试验
内科学
皮肤病科
病理
生物
遗传学
替代医学
细菌
作者
Vicente Navarro-López,Asunción Martínez‐Andrés,A. Ramírez-Boscá,Beatriz Ruzafa-Costas,Eva Núñez‐Delegido,Miguel A Carrión-Gutiérrez,David Prieto‐Merino,Francisco M. Codoñer-Cortés,Daniel Ramón-Vidal,Salvador Genovés-Martínez,Empar Chenoll,Jose Manuel Pérez-Orquín,José Antonio Picó-Monllor,Sara Chumillas-Lidón
标识
DOI:10.2340/00015555-3305
摘要
The aim of this 12-week randomized, double-blind, placebo-controlled trial was to determine the efficacy and safety of a probiotic mixture in the reduction of psoriasis severity. Ninety 18-70-year-old adults with plaque psoriasis were randomized into probiotic and placebo groups. At 12-week follow-up, 66.7% of patients in the probiotic group and 41.9% in the placebo group showed a reduction in Psoriasis Area and Severity Index of up to 75% (p < 0.05). A clinically relevant difference was observed in Physician Global Assessment index: 48.9% in the probiotic group achieved a score of 0 or 1, compared with 30.2% in the placebo group. The results of follow-up 6 months after the end of the study showed a lower risk of relapse after the intake of the probiotic mixture. Analysis of gut microbiota confirmed the efficacy of the probiotic in modulation of the microbiota composition.
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