青霉素
医学
金黄色葡萄球菌
青霉素
微生物学
抗生素
葡萄球菌感染
青霉素耐药性
细菌
生物
遗传学
作者
W. Brumfitt,J. M. T. Hamilton‐Miller
标识
DOI:10.1056/nejm198905043201806
摘要
STAPHYLOCOCCUS AUREUS is one of the most versatile human pathogens. In the late 1930s, sulfonamides offered the first challenge to S. aureus, but they failed because of their poor clinical performance in the presence of pus and the acquisition of resistance by the bacteria.1 In the early 1940s the introduction of benzylpenicillin (penicillin G) temporarily solved the problem of staphylococcal infections, but the continued use of this agent caused the selection of resistant strains, which produced penicillinase (β-lactamase). By 1948 the prevalence of resistant strains had seriously reduced the value of benzylpenicillin.2 By the end of the 1950s, S. . . .
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