毒性
氧化应激
褪黑素
邻苯二甲酸盐
肾
肿瘤坏死因子α
炎症
医学
化学
药理学
内分泌学
免疫学
内科学
有机化学
作者
Ping Ma,Biao Yan,Qiang Zeng,Xudong Liu,Yang Wu,Ming Jiao,Chao Liu,Jiliang Wu,Xu Yang
标识
DOI:10.1016/j.fct.2014.03.027
摘要
Diisononyl phthalate (DINP) has been widely used in polyvinyl chloride (PVC) products and is ubiquitous as a substitute; however, its toxicity due to exposure remains to be determined. This study investigated the oxidative damage induced by DINP and the induced production of the pro-inflammation cytokines interleukin-1 (IL-1) and tumour necrosis factor-α (TNF-α). Oral exposure to DINP induced oxidative damage and inflammatory responses in liver and kidney tissues through the accumulation of ROS, which may be an underlying mechanism for its toxicity. These changes may contribute to hepatic and renal histopathological alterations. Our data suggest that oxidative stress is involved in DINP-induced toxicity and that the co-administration of melatonin exerts a protective effect against DINP-induced toxicity.
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