乳腺癌
雌激素受体
男性乳腺癌
生物
转录组
雄激素受体
癌症
疾病
雌激素
基因
肿瘤科
雌激素受体α
临床意义
雄激素
内科学
基因表达
生物信息学
内分泌学
医学
遗传学
激素
前列腺癌
作者
Maurizio Callari,Vera Cappelletti,Loris De Cecco,Valeria Musella,Patrizia Miodini,Silvia Veneroni,Manuela Gariboldi,Marco A. Pierotti,Maria Grazia Daidone
标识
DOI:10.1007/s10549-010-1015-8
摘要
Male breast cancer (MBC) is a poorly characterized disease because of its rarity. Clinical management is based on results obtained from randomized trials conducted in women notwithstanding data in the literature suggesting relevant gender-associated differences in terms of biological and clinical behavior. However, a genome-wide characterization of MBC on a transcriptional level is lacking. In this study, gene expression profiles of 37 estrogen receptor positive (ER+) MBC specimens were compared to that of 53 ER+ Female Breast Cancer (FBC) samples similar for clinical and patho-biological features. Almost 1000 genes were found differentially expressed (FDR < 1%) between female and male patients and biological interpretation highlighted a gender-associated modulation of key biological processes ranging from energy metabolism to regulation of translation and matrix remodeling as well as immune system recruitment. Moreover, an analysis of genes correlated to steroid receptors and ERBB2 suggested a prominent role for the androgen receptor in MBC with a minor relevance for progesterone receptor and ERBB2, although, similarly to FBC, a genomic amplification could be observed. Our findings support the idea that breast cancer is a quite different disease in male and female patients and the underlying gender-related biological differences are likely to have clinical implications connected with different susceptibility to treatment.
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