星形胶质细胞
促炎细胞因子
小胶质细胞
生物
免疫学
炎症
转基因小鼠
受体
神经胶质
电池类型
细胞生物学
细胞
转基因
中枢神经系统
神经科学
基因
遗传学
作者
Sophie Desplat‐Jégo,S. Varriale,Rita Creidy,Rafik Terra,Dominique Bernard,Michel Khrestchatisky,Shozo Izui,Yves Chicheportiche,José Boucraut
标识
DOI:10.1016/s0165-5728(02)00368-5
摘要
TWEAK is a new TNF family member with proinflammatory and proliferative effects on different cell types, mediated by the recently identified Fn14 receptor. TWEAK expression was analyzed on mouse microglial cells and astrocytes. Both cell types express TWEAK mRNA. Astrocytes expressed Fn14 and proliferated in the presence of rTWEAK. TWEAK mRNA is expressed in normal CNS and its steady state level increases in spinal cord during EAE. Finally, EAE severity is enhanced in soluble TWEAK-overexpressing transgenic mice. These results support the contention that TWEAK is involved in CNS inflammation.
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