Octreotide-modified pH-responsive nanocomposites for ultrasound imaging-guided chemo-photothermal therapy of prostate cancer

, IDOCP@CC combined with NIR irradiation markedly increased reactive oxygen species generation, induced apoptosis and cell death, inhibited migration and colony formation, and promoted immunogenic cell death-associated signals. In PC3 xenograft-bearing nude mice, IDOCP@CC accumulated efficiently in tumors, enhanced contrast-enhanced ultrasound imaging, elevated tumor temperature under NIR irradiation, achieved a tumor inhibition rate of 69%, reduced serum PSA levels, downregulated β-catenin expression, and showed no obvious systemic toxicity. These findings suggest that IDOCP@CC is a promising octreotide-modified and pH-responsive theranostic nanoplatform for ultrasound imaging-guided chemo-photothermal therapy of prostate cancer.