Purpose: Unilateral cleft lip and palate is a defect involving the lip, nose and maxilla. These structures are inter-related, and simultaneous early correction of all the aspects of the defect is necessary to obtain a satisfactory result that will be maintained with growth. There are few reports about oral rehabilitation with dental implants, in patients with this condition in the literature.Material and Method: The presented case report describes the clinical and surgical management of a patient with unilateral alveolar cleft associated to severe posterior maxilla bone resorption. This patient was treated with 2 zygomatic implants (S.I.N.-Implant System, Sa o Paulo, Brazil) in the posterior maxilla and 4 standard axial implants in the anterior maxilla.Results: The patient is on ten years of postoperative without complaints.Conclusion: The high survival rate, the increase of patients’ demand in immediate functional ability and the less morbidity following the surgical procedure renders this zygomatic implant procedure a viable treatment option of the resorbed fully edentulous maxilla.