Electrochemical Aspects of Mass Spectrometry: Atmospheric Pressure Ionization and Ambient Ionization for Bioanalysis

Abstract This MiniReview details the evolution and present state of combined electrochemical (EC) and atmospheric pressure sampling/ionization mass spectrometric (MS) techniques, with an emphasis on biologically relevant investigations. Particular attention is paid to how innate EC processes can be exploited to gain additional information about an analyte, and how these effects influence experimental design. A general overview of EC‐MS techniques underscores the complementary nature of the two techniques.