Stereoselective Synthesis of cis‐2,5‐Disubstituted Pyrrolidines via Copper‐Catalyzed Cyclization of Alkenes

Abstract An efficient methodology for the stereoselective synthesis of cis ‐2,5‐disubstituted pyrrolidines using copper catalyst was developed. The corresponding cis ‐2,5‐disubstituted pyrrolidines could be obtained in reasonable yields and with good stereoselectivities in the presence of 4,4′‐di‐ tert ‐butyl‐2,2′‐bipyridine as ligand and 1‐methyl‐2‐pyrrolidinone as solvent.