[Effectiveness of autologous hematopoietic stem cells transplantation in patients with liver cirrhosis].

Liver cirrhosis is a problem that requires new therapeutical approaches because the existing treatment is not effective enough. The most promising at present may be new treatments in the field of regenerative medicine and in particular the use stem cells. Autologous hematopoietic stem cells were injected into the celiac trunk of patients with alcoholic cirrhosis. Liver biopsy specimens were stained immunohistochemically with antibodies against CD 34, alpha-smooth-muscle actin (a-SMA) and Bcl-2. The results showed that this approach is effective in suppression of fibrogenesis in liver and immunohistochemical methods are highly informative in assessing the effectiveness of stem cells transplantation.