Evaluation of the Clinical Effects of Ptoglitazone Hydrochliride in Treatment of Type 2 Diabetes

Objective: To evaluate the clinical effects of pioglitazone hydrochliride in treatment of type 2 diabetes. Methods: 86 cases with 2 diabetic were enrolled, they were divided into two groups: Group A and Group B. in Group A the patients were treated only with sulphonylureas oral antihyperglycemic agents(men 24 and women 26); Group B the patients were treated with sulphonylureas oral antihyperglycemic agents and pioglitazone hydrochliride (men 19 and women 17) .A statistical analysis of the changes that took place in the patient's weight、lipid and sugar metablism before and after the treatment was performed. Results:The blood glucose lev-els(PBG、FBG、HbAlc)of the cases in Group B decreased more quickly than the cases in Group A after the treament,and the blood glucose levels between cases of the two groups were statistically different (P 0.05); After 12 weeks' treatment,the changes of the insulin level was that Group A increased and Group B decreased (the PINS'decrease reached statistical significance (P 0.01) ,but the FINS' decrease didn' s reach statistical significance), and the difference of FINS between the two groups reached statistical significance ( P 0.05). Although after 12 weeks' treatment, the TC and TG of the cases in Group B decreased obviously, they were not different from the cases in Group A in statistical significance.The changes of HDL-c and BMI in the two groups didn't show statistical significance. Conclusion: Pioglitazone hydrochliride can reduce insulin resistance in the cases with type 2 diabetes,and adjust the disorder of lipid and sugar metablism without the increase of weight.