Roles of Neutrophil Elastase Inhibitors in Diseases

Neutrophil-derived elastase promotes destruction of the tissue,increases vascular permeability,and promotes neutrophil migration.Neutrophil elastase inhibitors(NEI) reduce tissue injury which through inhibition of neutrophil elastase(NE) activity.They also have anti-inflammatory and immunomodulatory properties.Recent studies found that NEI provide protection against organ damage in particular of neutrophil-mediated tissue injury.This review was focused on the role of NEI in some diseases.