Oxygen in tissue is different since it diffuse from vessel. The hematoporphyrin sensitizer used in Photodynamic therapy produce toxic substance through translating energy to oxygen molecule,so the distribution of oxygen in tissue have special value as there has consumption of oxygen during photodynamic therapy.This is a summarize about oxygen distribution in aim and normal tissue,the effect of photodynamic action on oxygen content in tissue and oxygen content's reaction to photodynamic therapy.