感染性休克
败血症
医学
肺炎
血管生成素
内科学
免疫学
外周血单个核细胞
器官功能障碍
胃肠病学
生物
体外
生物化学
血管内皮生长因子
血管内皮生长因子受体
作者
Korina Lymperopoulou,Dimitrios Velissaris,Antigone Kotsaki,E. Antypa,Sara Georgiadou,Θωμάς Τσαγανός,Despoina Koulenti,Evgenia Paggalou,Georgia Damoraki,Napoleon Karagiannidis,Stylianos E. Orfanos
出处
期刊:Cytokine
[Elsevier]
日期:2015-05-01
卷期号:73 (1): 163-168
被引量:28
标识
DOI:10.1016/j.cyto.2015.01.022
摘要
Angiopoietin-2 (Ang-2) is an important mediator in sepsis. We have previously shown that endotoxemia levels are related to the underlying infection and affect septic patients' outcome. Based on this background we now investigated if circulating Ang-2 (cAng-2) and monocyte Ang-2 expression in septic patients are associated with the underlying infection and organ failure. We measured cAng-2 in 288 septic patients (121 with sepsis, 167 with severe sepsis/septic shock) at less than 24h post study inclusion (day 1) and on days 3 and 7. Peripheral blood mononuclear cells (PBMCs) were additionally isolated; Ang-2 gene expression was estimated by means of real-time PCR. Levels of cAng-2 were higher under severe sepsis and septic shock, as compared to uncomplicated sepsis; PBMC Ang-2 copies were higher in severe sepsis. On day 1, cAng-2 and Ang-2 gene copies were greater under severe sepsis/septic shock in sufferers from all types of infections with the exception of community-acquired pneumonia and ventilator-associated pneumonia. cAng-2 increased proportionally to the number of failing organs, and was higher under metabolic acidosis and acute coagulopathy as compared to no failing organ. On day 1, copies of Ang-2 were higher in survivors, whereas cAng-2 was higher in non-survivors. In a large cohort of septic patients, cAng-2 kinetics appears associated with the underlying infection and organ failure type.
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