材料科学
纳米颗粒
胶体金
二硫键
联轴节(管道)
谷胱甘肽
纳米技术
化学工程
复合材料
有机化学
生物化学
工程类
酶
化学
作者
Yupeng Shi,Heng Zhang,Zhenfeng Yue,Zhaomin Zhang,Kar-Seng Teng,Meijin Li,Changqing Yi,Mengsu Yang
出处
期刊:Nanotechnology
[IOP Publishing]
日期:2013-08-23
卷期号:24 (37): 375501-375501
被引量:45
标识
DOI:10.1088/0957-4484/24/37/375501
摘要
Advances in the controlled assembly of nanoscale building blocks have resulted in functional devices which can find applications in electronics, biomedical imaging, drug delivery etc. In this study, novel covalent nanohybrid materials based upon [Ru(bpy)3](2+)-doped silica nanoparticles (SiNPs) and gold nanoparticles (AuNPs), which could be conditioned as OFF-ON probes for glutathione (GSH) detection, were designed and assembled in sequence, with the disulfide bonds as the bridging elements. The structural and optical properties of the nanohybrid architectures were characterized using transmission electron microscopy, UV-vis spectroscopy and fluorescence spectroscopy, respectively. Zeta potential measurements, x-ray photoelectron spectroscopy and Fourier transform infrared spectroscopy were employed to monitor the reaction processes of the SiNPs-S-S-COOH and SiNPs-S-S-AuNPs synthesis. It was found that the covalent nanohybrid architectures were fluorescently dark (OFF state), indicating that SiNPs were effectively quenched by AuNPs. The fluorescence of the OFF-ON probe was resumed (ON state) when the bridge of the disulfide bond was cleaved by reducing reagents such as GSH. This work provides a new platform and strategy for GSH detection using covalent nanohybrid materials.
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