电池类型
小胶质细胞
生物
大脑皮层
皮质(解剖学)
海马体
细胞
单细胞分析
细胞生物学
转录组
核糖核酸
神经科学
基因表达
基因
遗传学
免疫学
炎症
作者
Amit Zeisel,Ana B. Muñoz‐Manchado,Simone Codeluppi,Peter Lönnerberg,Gioele La Manno,Anna Juréus,Sueli Marques,Hermany Munguba,Liqun He,Christer Betsholtz,Charlotte Rolny,Gonçalo Castelo‐Branco,Jens Hjerling‐Leffler,Sten Linnarsson
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:2015-03-06
卷期号:347 (6226): 1138-1142
被引量:2746
标识
DOI:10.1126/science.aaa1934
摘要
Cellular diversity in the brain revealed The mammalian brain has an extraordinarily large number of cells. Although there are quite a few different cell types, many cells in any one category tend to look alike. Zeisel et al. analyzed the transcriptomes of mouse brain cells to reveal more than meets the eye. Interneurons of similar type were found in dissimilar regions of the brain. Oligodendrocytes that seemed to be all of one class were differentiated by their molecular signatures into a half-dozen classes. Microglia associated with blood vessels were distinguished from look-alike perivascular macrophages. Thus, the complex microanatomy of the brain can be revealed by the RNAs expressed in its cells. Science , this issue p. 1138
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