甲基化
精氨酸
髓鞘碱性蛋白
髓鞘
脑脊髓炎
生物化学
化学
酶
瓜氨酸化
人脑
生物
氨基酸
瓜氨酸
免疫学
中枢神经系统
多发性硬化
神经科学
DNA
作者
Graham S. Baldwin,P. R. Carnegie
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:1971-02-12
卷期号:171 (3971): 579-581
被引量:188
标识
DOI:10.1126/science.171.3971.579
摘要
A cytoplasmic enzyme from guinea pig brain was shown to transfer methyl groups from S-adenosylmethionine to only one of 19 arginine residues in the basic protein from human brain. The products were omega-N-monomethylarginine and omega-N,N'-dimethylarginine. These methylated arginines are adjacent to the main encephalitogenic determinant in the protein. Methylation may aid in the transfer of this region of the protein into the nonpolar environment within myelin and in maintaining the integrity of myelin.
科研通智能强力驱动
Strongly Powered by AbleSci AI