柑橘衰退病毒
生物
克隆病毒
基因组
病毒
病毒学
遗传学
植物病毒
计算生物学
核糖核酸
基因
作者
Pedro R. Moreno,Carmelo López,Susana Ruiz-Ruiz,Leandro Peña,José Guerri
出处
期刊:Virus Research
[Elsevier]
日期:2022-03-01
卷期号:314: 198755-198755
被引量:2
标识
DOI:10.1016/j.virusres.2022.198755
摘要
Knowledge on diseases caused by Citrus tristeza virus (CTV) has greatly increased in last decades after their etiology was demonstrated in the past seventies. Professor Ricardo Flores substantially contributed to these advances in topics like: i) improvement of virus purification to obtain biologically active virions, ii) sequencing mild CTV isolates for genetic comparisons with sequences of moderate or severe isolates and genetic engineering, iii) analysis of genetic variation of both CTV genomic RNA ends and features of the highly variable 5' end that allow accommodating this variation within a conserved secondary structure, iv) studies on the structure, subcellular localization and biological functions of the CTV-unique p23 protein, and v) potential use of p23 and other 3'-proximal regions of the CTV genome to develop transgenic citrus resistant to the virus. Here we review his main achievements on these topics and how they contributed to deeper understanding of CTV biology and to new potential measures for disease control.
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