三苯胺
材料科学
超分子化学
溶酶体
超分子组装
荧光
发光
罗丹明
光化学
纳米技术
生物物理学
化学
高分子化学
有机化学
光电子学
分子
酶
物理
量子力学
作者
Jie Yu,Hui Wang,Xianyin Dai,Yong Chen,Yu Liu
标识
DOI:10.1021/acsami.1c19698
摘要
Near-infrared (NIR) targeted cell imaging has become a research hotspot due to the advantages of deeper tissue penetration, minimal interference from the background signals, and lower light damage. Herein, we report a multivalent supramolecular aggregate with NIR fluorescence emission, which was fabricated from triphenylamine derivatives (TPAs), cucurbit[8]uril (CB[8]), Si-rhodamine (SiR), and hyaluronic acid (HA). Interestingly, possessing a rigid luminescent core and cationic phenylpyridinium units linked by flexible alkyl chains, the tripaddle hexacationic TPA could bind with CB[8] at a 2:3 stoichiometric ratio to form a network-like multivalent assembly with enhanced red luminescence. Such organic two-dimensional network-like aggregate further co-assembled with the energy acceptor SiR and cancer cell targeting agent HA, leading to nanoparticles with NIR emission at 675 nm via an intermolecular energy transfer pathway. Furthermore, the obtained multivalent supramolecular aggregate was successfully applied in lysosome targeted imaging toward A549 cancer cells, which provides a convenient strategy for NIR targeted cell imaging.
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