Carbon Monoxide in Organic Synthesis

The first Rh(I)-catalyzed regioselective arylcarboxylation of electron-deficient acrylamides with arylboronic acids under atmospheric pressure of CO 2 has been developed.A range of acrylamides and arylboronic acids were compatible with this reaction under redox-neutral conditions, leading to a series of malonate derivatives that are versatile building blocks in organic syntheses.Scheme 1 Carboxylation of alkenes with CO 2 .