Advances in the Synthesis of Vinyl Chloride Compounds

Vinyl chloride is an important functional group in many biologically and pharmaceutically active compounds, some vinyl chloride derivatives have been employed as organic materials, including polymers, and also are employed as the building block in organic synthesis. The construction of vinyl chloride is widely studied, new method and reagent are continuing to emerge in recently years. In this paper, the recent progress in the synthesis of vinyl chloride is reviewed according to the different reaction types, and its application in the total synthesis of marine natural product malyngamides is covered.