化学
四氢异喹啉
核黄素
光催化
利乐
光化学
氧化还原
电子转移
辅因子
催化作用
组合化学
酶
有机化学
药物化学
生物化学
作者
Yunfei Song,Xinhao Wang,Lin Wang,Zhuang Dong,Shulin Fan,Pilin Huang,Jianguo Zeng,Pi Cheng
标识
DOI:10.1016/j.tetlet.2021.153286
摘要
Riboflavin (RF) and relative derivatives are important coenzyme of some redox enzymes controlling the growing development of plants by harvesting light. The unique isoalloxazine structure unit with special photoredox capacity makes it applicable to induce single electron transfer (SET) oxidation of organic molecules. We report here that riboflavin tetra-acetate (RFTA) catalyzed the oxidation of N-phenyl tetrahydroisoquinoline to α-amino C-radical which subsequently undergoes radical type Michael addition to CC double bond of allylsulfone to access 1-allylated N-phenyl tetrahydroisoquinoline.
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