介孔材料
介孔二氧化硅
药物输送
溶解
赋形剂
剂型
药品
纳米技术
材料科学
化学
溶解试验
毒品携带者
生物利用度
溶解度
药理学
色谱法
化学工程
有机化学
医学
催化作用
生物制药分类系统
工程类
作者
Ana Baumgartner,Odon Planinšek
标识
DOI:10.1016/j.ejps.2021.106015
摘要
Due to the high number of poorly water-soluble active pharmaceutical ingredients, oral drug delivery development has become challenging. One of the strategies to enhance drug solubility and to achieve high oral bioavailability is to formulate such compounds into amorphous solid dispersions. In recent years, porous materials have been investigated as possible carriers into which a drug can be adsorbed, such as mesoporous silica, in particular. Unlike the ordered mesoporous network of silica, non-ordered silica already has a "generally regarded as safe" status, and is already used as an excipient in pharmaceutical and cosmetic products. Thus, it is reasonable to expect that products that contain solid dispersions with non-ordered carriers will reach the market sooner and more easily than those with ordered mesoporous carriers. The emphasis of this review is therefore on non-ordered commercially available mesoporous silica and the progress that has been made in development of the use of these materials for improved dissolution rates in oral drug delivery. First, a thorough categorisation of the drug loading methods is presented, followed by discussion on the most important characteristics of solid dispersions (i.e., physical state, stability, drug release). Finally, manufacturability and production of a final solid dosage form are considered.
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