细菌素
抗菌剂
抗菌肽
细菌
微生物学
抗生素耐药性
抗生素
生物
遗传学
作者
Hadis Fathizadeh,Farzaneh Pakdel,Mahmood Saffari,Davoud Esmaeili,Mansooreh Momen-Heravi,Sounkalo Dao,Khudaverdi Ganbarov,Xiao Chen
出处
期刊:Current Pharmaceutical Biotechnology
[Bentham Science]
日期:2021-09-07
卷期号:23 (8): 1028-1040
被引量:2
标识
DOI:10.2174/1389201022666210907121254
摘要
Due to the emergence and development of antibiotic resistance in the treatment of bacterial infections, efforts to discover new antimicrobial agents have increased. One of these antimicrobial agents is a compound produced by a large number of bacteria called bacteriocin. Bacteriocins are small ribosomal polypeptides that can exert their antibacterial effects against bacteria close to their producer strain or even non-closely-relatedstrains. Adequate knowledge of the structure and functional mechanisms of bacteriocins and their spectrum of activity, as well as knowledge of the mechanisms of possible resistance to these compounds, will lead to further development of their use as an alternative to antibiotics. Furthermore, most bacteria that live in the gastrointestinal tract (GIT) have the ability to produce bacteriocins, which spread throughout the GIT. Despite antimicrobial studies in vitro, our knowledge of bacteriocins in the GIT and the migration of these bacteriocins from the epithelial barrier is low. Hence, in this study, we reviewed general information about bacteriocins, such as classification, mechanism of action and resistance, emphasizing their presence, stability, and spectrum of activity in the GIT.
科研通智能强力驱动
Strongly Powered by AbleSci AI