Can we use radiomics in ultrasound imaging? Impact of preprocessing on feature repeatability

The purpose of this study was to assess the inter-slice radiomic feature repeatability in ultrasound imaging and the impact of preprocessing using intensity standardization and grey-level discretization to help improve radiomics reproducibility.This single-center study enrolled consecutive patients with an orbital lesion who underwent ultrasound examination of the orbit from December 2015 to July 2019. Two images per lesion were randomly assigned to two subsets. Radiomic features were extracted and inter-slice repeatability was assessed using the intraclass correlation coefficient (ICC) between the subsets. The impact of preprocessing on feature repeatability was assessed using image intensity standardization with or without outliers removal on whole images, bounding boxes or regions of interest (ROI), and fixed bin size or fixed bin number grey-level discretization. Number of inter-slice repeatable features (ICC ≥0.7) between methods was compared.Eighty-eight patients (37 men, 51 women) with a mean age of 51.5 ± 17 (SD) years (range: 20-88 years) were enrolled. Without preprocessing, 29/101 features (28.7%) were repeatable between slices. The greatest number of repeatable features (41/101) was obtained using intensity standardization with outliers removal on the ROI and fixed bin size discretization. Standardization performed better with outliers removal than without (P < 0.001), and on ROIs than on native images (P < 0.001). Fixed bin size discretization performed better than fixed bin number (P = 0.008).Radiomic features extracted from ultrasound images are impacted by the slice and preprocessing. The use of intensity standardization with outliers removal applied to the ROI and a fixed bin size grey-level discretization may improve feature repeatability.