遗传密码
合成生物学
计算生物学
翻译(生物学)
生物
氨基酸
基因组
编码(集合论)
计算机科学
遗传学
程序设计语言
基因
信使核糖核酸
集合(抽象数据类型)
作者
Hongting Tang,Zhiyong Pan,Xiaozhou Luo
标识
DOI:10.1016/j.jmb.2021.167382
摘要
Genetic code expansion (GCE) enables the site-specific incorporation of non-canonical amino acids as novel building blocks for the investigation and manipulation of proteins. The advancement of genetic code expansion has been benefited from the development of synthetic biology, while genetic code expansion also helps to create more synthetic biology tools. In this review, we summarize recent advances in genetic code expansion brought by synthetic biology progresses, including engineering of the translation machinery, genome-wide codon reassignment, and the biosynthesis of non-canonical amino acids. We highlight the emerging application of this technology in construction of new synthetic biology parts, circuits, chassis, and products.
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