线粒体
嘧啶代谢
肿瘤进展
呼吸
化学
嘧啶
线粒体DNA
生物化学
肿瘤细胞
转移RNA
癌症
新陈代谢
生物合成
生物
细胞呼吸
细胞生物学
癌症研究
癌细胞
DNA
DNA合成
核糖核酸
作者
Maria Dubisova,Klára Boháčová,Zuzana Nahácka,Daniel Kraus,Jaromı́r Novák,Šárka Dvořáková,Petra Brisudová,Natalie Danesova,Saba Selvi,Mariia Hrysiuk,Berwini Endaya,Panagiotis Botsios,Dan‐Diem Thi Le,Monika Novotna,Soňa Vodenková,Jaroslav Truksa,Karel Chalupský,Kryštof Klíma,Jan Procházka,Radislav Sedláček
出处
期刊:Cancer Research
[American Association for Cancer Research]
日期:2025-11-17
卷期号:86 (4): 925-939
标识
DOI:10.1158/0008-5472.can-24-0737
摘要
Mitochondrial complexes III and IV promote tumor progression by supporting de novo pyrimidine synthesis, requiring cancer cells devoid of mitochondrial DNA to recruit mitochondria from source cells to restore respiration in order to form tumors.
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