Intravenous Multifunctional Nanotherapy for Treating Dry Age‐Related Macular Degeneration (Adv. Healthcare Mater. 29/2025)

Age-Related Macular Degeneration Like hot-air balloons delivering cargo, the multifunctional micellar system, APMNP@Rapa, specifically targets damaged retinal pigment epithelium (RPE) in dry AMD and releases therapeutic payload in response to high ROS levels. By coordinately attenuating oxidative damage, suppressing inflammation, and inhibiting aberrant mTOR activation, APMNP@Rapa effectively restores the retinal microenvironment and preserves the characteristic hexagonal architecture and monolayer integrity of RPE cells. More details can be found in the Research Article by Tao Sun, Chen Jiang, Chen Zhao, and co-workers (DOI: 10.1002/adhm.202502925).