卵清蛋白
鼻粘膜
TLR4型
医学
氧化应激
免疫学
NF-κB
NFKB1型
促炎细胞因子
药理学
血红素加氧酶
细胞因子
受体
炎症
血红素
化学
转录因子
内分泌学
内科学
生物化学
抗原
基因
酶
作者
Bo Tian,Xin Ma,Rui Jiang
标识
DOI:10.1177/19458924221124363
摘要
Allergic rhinitis (AR) is an inflammatory disorder of nasal mucosa resulting from allergen exposure. Daphnetin (DAP) is a coumarin derivative that has various bioactivities. Nevertheless, its specific function in AR is unclear.This study is aimed to explore the specific function of DAP in AR.An AR murine model was established by ovalbumin (OVA) induction. Murine sneezing and rubbing behaviors were observed. Hematoxylin-eosin was used for histopathological observation of nasal mucosa. ELISA was utilized for detection of cytokine production in murine serum. Oxidative stress-associated markers were assessed by commercial assay kits. Western blotting was utilized for evaluating protein levels of Toll-like receptor 4 (TLR4) and nuclear factor kappa B (NF-κB) in nasal mucosa.DAP alleviated OVA-induced nasal symptoms, inflammatory response and oxidative stress in the AR murine model. DAP activated nuclear factor erythroid 2-related factor 2/heme oxygenase-1 (Nrf2/HO-1) signaling and inactivated TLR4/NF-κB signaling in murine nasal mucosa.DAP mitigates OVA-induced AR in mice by activating Nrf2/HO-1 signaling and inactivating TLR4/NF-κB signaling.
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