适体
Abcg2型
多重耐药
化学
纳米技术
高价分子
纳米颗粒
胶体金
癌症研究
材料科学
分子生物学
ATP结合盒运输机
生物化学
生物
运输机
试剂
基因
物理化学
抗生素
作者
Wei Lu,Jingran Chen,Zhanchen Guo,Yanyan Ma,Zikuan Gu,Zhen Liu
摘要
Hypervalent bispecific gold nanoparticle-anchored aptamer chimeras (AuNP-APTACs) were designed as a new tool of lysosome-targeting chimeras (LYTACs) for efficient degradation of the ATP-binding cassette, subfamily G, isoform 2 protein (ABCG2) to reverse multidrug resistance (MDR) of cancer cells. The AuNP-APTACs could effectively increase the accumulation of drugs in drug-resistant cancer cells and provide comparable efficacy to small-molecule inhibitors. Thus, this new strategy provides a new way to reverse MDR, holding great promise in cancer therapy.
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