伦瓦提尼
医学
癌症研究
肝细胞癌
体内
癌
动物模型
癌症
肿瘤细胞
肝癌
放射治疗
作者
Agavni Mesropian,Albert Gris‐Oliver,Ugne Balaseviciute,Alka A. Potdar,Takayuki Kimura,Jialing Shen,Martí Torres-Marcén,Jordi Abril‐Fornaguera,Marta Piqué‐Gili,David Camell-Raventos,Judit Peix,Elisa Fernández‐Martínez,Júlia Huguet‐Pradell,Ana Hernández de Sande,Ieva Keraite,Roger Esteban-Fabró,Marina Bárcena‐Varela,Katherine E. Lindblad,Amaia Lujambio,Ernesto Guccione
标识
DOI：10.1158/1078-0432.ccr-25-0725
摘要
E7386 sensitized tumors to lenvatinib, thereby enhancing survival in mice compared with either monotherapy. In patients, E7386 combined with lenvatinib promoted tumor shrinkage and, in parallel, activated ATF4 signaling.
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(2025-6-4)
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