Single-cell and bulk transcriptomic analyses reveal PANoptosis-associated immune dysregulation of fibroblasts in periodontitis

Our findings demonstrate that PANoptosis is activated in HGFs in the context of PD, which may drive immune dysregulation and facilitate disease progression. By integrating bulk transcriptomic data with machine learning algorithms, we identified and validated key PANoptosis-related genes, highlighting their potential as novel therapeutic targets.