溶瘤病毒
牛痘
溶癌病毒
临床试验
病毒
医学
免疫疗法
癌症
肿瘤微环境
遗传增强
癌症研究
病毒学
免疫学
生物
基因
肿瘤细胞
内科学
生物化学
重组DNA
作者
Mengyuan Li,Minghuan Zhang,Qian Ye,Yun-Hua Liu,Wenbin Qian
标识
DOI:10.20892/j.issn.2095-3941.2023.0202
摘要
Oncolytic virotherapy has emerged as a promising treatment for human cancers owing to an ability to elicit curative effects via systemic administration. Tumor cells often create an unfavorable immunosuppressive microenvironment that degrade viral structures and impede viral replication; however, recent studies have established that viruses altered via genetic modifications can serve as effective oncolytic agents to combat hostile tumor environments. Specifically, oncolytic vaccinia virus (OVV) has gained popularity owing to its safety, potential for systemic delivery, and large gene insertion capacity. This review highlights current research on the use of engineered mutated viruses and gene-armed OVVs to reverse the tumor microenvironment and enhance antitumor activity in vitro and in vivo, and provides an overview of ongoing clinical trials and combination therapies. In addition, we discuss the potential benefits and drawbacks of OVV as a cancer therapy, and explore different perspectives in this field.
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