药效团
芳基
砜
烷基
化学
组合化学
有机化学
钠
选择性
催化作用
立体化学
作者
Palasetty Chandu,Manasi Mallick,Vinjamuri Srinivasu,Devarajulu Sureshkumar
标识
DOI:10.1002/chem.202303187
摘要
Abstract Allyl sulfones are an essential pharmacophore in many bioactive compounds. To combat their synthetic barrier, we report a practical, straightforward organophotocatalyzed methodology for accessing miscellaneously functionalized allyl sulfone derivatives using inexpensive and bench‐stable sodium sulfinate salts under mild conditions. This photo‐catalyzed radical sulfonylation provides access to a variety of allyl sulfones in good to excellent yields with high E : Z selectivity. A wide range of vinyl cyclopropanes, as well as aryl/hetero and alkyl sodium sulfinates, were tolerated and reliable in gram‐scale synthesis. Later on, further functionalization of allyl sulfones was demonstrated. A plausible mechanism for radical sulfonylation is proposed from the control experiments.
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