嵌合抗原受体
胰腺癌
肿瘤微环境
癌症研究
细胞毒性T细胞
癌细胞
T细胞
免疫学
医学
癌症
生物
免疫系统
体外
内科学
生物化学
作者
Ruixin Sun,Liu Yifan,Yansha Sun,Min Zhou,Dong Yiwei,HU Xiao-li,Bizhi Shi,Hua Jiang,Zonghai Li
摘要
The dual-targeted CAR-T cells obtained enhancement of T effector function, inhibition of T cell exhaustion, and improvement of tumour microenvironment. Our findings provide a theoretical rationale for dual-targeted FAP/CLDN 18.2 CAR-T cells therapy in PDAC.
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