Piezoelectric Heterojunctions as Bacteria‐Killing Bone‐Regenerative Implants

Heterojunctions are widely used in energy conversion, environmental remediation, and photodetection, but have not been fully explored in regenerative medicine. In particular, piezoelectric heterojunctions have never been examined in tissue regeneration. Here the development of piezoelectric heterojunctions is shown to promote bone regeneration while eradicating pathogenic bacteria through light-cellular force-electric coupling. Specifically, an array of heterojunctions (TiO₂/Bi₂WO₆), made of piezoelectric nanocrystals (Bi₂WO₆) decorating TiO₂ nanowires, is fabricated as a biocompatible implant. Upon exposure to near-infrared light, the piezoelectric heterojunctions generate reactive oxygen species and heat to kill bacteria through photodynamic and photothermal therapy, respectively. Meanwhile, the mechanical forces of the stem cells grown on the implant trigger the heterojunctions to produce electric fields that further promote osteogenesis to achieve osteointegration. The heterojunctions effectively suppress postoperative recurrent infections while promoting osseointegration through the local electric fields induced by cells. Therefore, the piezoelectric heterojunctions represent a promising antibacterial tissue-regenerative implant.