Synthesis of Fluorinated Tubastatin A Derivatives with Bi-, Tri-, and Tetracyclic Cap Groups: Molecular Docking with HDAC6 and Evaluation of in Vitro Antitumor Activity

Tubastatin A derivatives based on bi-, tri-, and tetracyclic cap groups were synthesized. Derivative 14f exhibits the best antiproliferative activity against SUNE1, and MDA-MB-231 cancer cells, with IC 50 values of 0.51 and 0.52 μM, respectively.