An Efficient Asymmetric Synthesis of Finerenone via Evans’ Chiral Auxiliary

This article reports a new application of Evans’ chiral auxiliary for an efficient asymmetric synthesis of finerenone. This new application successfully achieves the key step of stereoselective construction of the naphthyridine core of finerenone, with a high diastereomeric ratio (dr 86:14) and an 80% yield of the desired product via Evans’ chiral (R)‐4‐benzyl‐2‐oxazolidinone. The downstream transamidation of ethyl ester, with ammonia, leads to the formation of finerenone.