Assessing the relationship between different sleep traits and retinal neurodegenerative diseases: A bidirectional Mendelian randomization study

= 0.023). Reverse MR showed AMD was inversely associated with short sleep duration and chronotype. Sensitivity analyses supported result robustness. Mediation analysis identified six traits potentially linking chronotype to DR. These findings suggest sleep-related traits may be modifiable risk factors in RNDs, offering insights for early prevention and intervention.