Clinical Analysis of PRP Combined With Hyaluronic Acid Mesotherapy in the Treatment of Facial Chloasma

ABSTRACT Objective To study the safety and clinical effect of PRP combined with hyaluronic acid (HA) mesotherapy in the treatment of facial chloasma, to explore a safe and effective treatment option for chloasma. Methods 57 patients with chloasma who received mesotherapy were analyzed in this study. They were divided into 19 cases of the PRP combined with HA mesotherapy group (PRP+HA group), 20 cases of the PRP mesotherapy group (PRP group) and 18 cases of the hyaluronic acid mesotherapy group (HA group). The therapeutic effect of chloasma was evaluated at the fourth week after treatment, including the decrease rate of chloasma area and severity index (MASI), the effective rate, the decrease rate of pigment degree, the decrease rate of pigment area, and the decrease rate of pigment quantity. The patient's satisfaction and adverse reactions were investigated. The safety and efficacy of each group were compared and analyzed. Results The effective rate of chloasma treatment in the PRP group and the PRP+HA group was more than 50% at 4 weeks after treatment. The improvement of the above indexes in the PRP+HA group was better than those in the single treatment group. The satisfaction of the PRP+HA group was higher than that of the HA group, and the satisfaction of the other groups was not significantly different. There were no serious adverse reactions in the three groups. Conclusion PRP mesotherapy alone or combined with HA and PRP mesotherapy can effectively treat chloasma, and the combined treatment effect is better, which is worthy of clinical promotion.