Facile Fabrication of Poly(N‐vinyl pyrrolidone)‐Iodine Coating on TiO2 Nanotubes with Antibacterial and Osteoconductive Properties

Abstract Implants made of titanium (Ti) and its alloys are widely used in orthopedics and dentistry. However, the Ti‐based materials, due to their inherent surface bioinertness, lack antibacterial properties and osteoconductive activity, leading to an increased risk of bacterial infection post‐implantation and suboptimal osseointegration efficiency. Herein, an antibacterial and osteoconductive coating via polydopamineassisted immobilization of poly(N‐vinyl pyrrolidone)‐iodine (PVP‐I) on TiO 2 nanotubes named TNT‐DP‐I is constructed. The TNT‐DP‐I coating could rapidly kill 97.80% Gram‐positive Staphylococcus aureus ( S. aureus ) and 97.96% Gram‐negative Escherichia coli ( E. coli ) within 1 h, highlighting its superior antibacterial efficiency. Additionally, this coating effectively promoted pre‐osteoblasts MC3T3‐E1 adhesion, growth, and proliferation, demonstrating enhanced osteoconductivity. Meanwhile, TNT‐DP‐I coating demonstrated good mammalian cytocompatibility and hemocompatibility, suggesting its promising biosafety. Overall, this study presents a facile approach for reducing bacterial contamination and enhancing osseointegration of Ti implants.