肝毒素
虎耳草毒素
失语症
蓝藻
污染
螺旋藻(膳食补充剂)
环境化学
每日容许摄入量
微囊藻毒素
藻类
化学
生物
毒素
鱼腥藻
植物
微生物学
原材料
细菌
生态学
有机化学
体重
内分泌学
遗传学
作者
Audrey Roy-Lachapelle,Morgan Solliec,Maryse F. Bouchard,Sébastien Sauvé
出处
期刊:Toxins
[MDPI AG]
日期:2017-02-25
卷期号:9 (3): 76-76
被引量:103
标识
DOI:10.3390/toxins9030076
摘要
Algae dietary supplements are marketed worldwide as natural health products. Although their proprieties have been claimed as beneficial to improve overall health, there have been several previous reports of contamination by cyanotoxins. These products generally contain non-toxic cyanobacteria, but the methods of cultivation in natural waters without appropriate quality controls allow contamination by toxin producer species present in the natural environment. In this study, we investigated the presence of total microcystins, seven individual microcystins (RR, YR, LR, LA, LY, LW, LF), anatoxin-a, dihydroanatoxin-a, epoxyanatoxin-a, cylindrospermopsin, saxitoxin, and β-methylamino-l-alanine in 18 different commercially available products containing Spirulina or Aphanizomenon flos-aquae. Total microcystins analysis was accomplished using a Lemieux oxidation and a chemical derivatization using dansyl chloride was needed for the simultaneous analysis of cylindrospermopsin, saxitoxin, and β-methylamino-l-alanine. Moreover, the use of laser diode thermal desorption (LDTD) and ultra-high performance liquid chromatography (UHPLC) both coupled to high resolution mass spectrometry (HRMS) enabled high performance detection and quantitation. Out of the 18 products analyzed, 8 contained some cyanotoxins at levels exceeding the tolerable daily intake values. The presence of cyanotoxins in these algal dietary supplements reinforces the need for a better quality control as well as consumer's awareness on the potential risks associated with the consumption of these supplements.
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