The rational layout and location of logistics center has a great impact on thefunction and overall profit of it. An introduction to the general ways of how tochoose the location of distribution center is made and also the weak points ofthe current ones are pointed out. The main factors are decided and the general principles are established through the analysis. The model of logistics center site selection is set up, which aims at the utmost economic benefits. Besides, theconfirmation of the parameters and calculation processes are further discussed.This model can be applied to the policy-making and the optimization on this issue.