Neutrophil degranulation: therapeutic targets in [NTP]O mediated neutrophil degranulation

Extracellular nucleotide-induced stimulation and activation of peripheral blood neutrophil and subsequent degranulation plays a critical role in immediate type hypersensitivity reaction and other inflammatory diseases. The extracellular nucleotides stimulate a P2Y receptor(s) on human PMN with the pharmacological profile similar to that of the P2Y2 receptor. Based on a recent proposal on the molecular mechanism of [NTP]O-induced neutrophil degranulation, a scheme identifying the therapeutic targets, is suggested with potential avenues for attenuating PMN degranulation.